I-BET151, pan-BET family inhibitor (RMML-00120091)
Cat. No.: RMML-00120091
Category: Inhibitors & Activators
INQUIRY
1 mg
50 mg
An isoxazole class pan-BET family inhibitor.
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | An isoxazole class pan-BET family inhibitor.; CAS Number: 1300031-49-5; Purity: > 98%; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | pan-BET family |
|---|---|
| Biological Description | I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3 and BRD4 with IC50 values of 0.5, 0.25 and 0.79 µM, respectively. Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines. |
| Alternative Names | GSK1210151A |
| CAS Number | 1300031-49-5 |
| Chemical Name | 7-(3,5-Dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-pyridin-2-ylethyl]-3H-imidazo[4,5-c]quinolin-2-one |
| SMILES | CC(ON=C1C)=C1C2=CC(N=CC(N3)=C4N([C@H](C)C5=CC=CC=N5)C3=O)=C4C=C2OC |
| Molecular Formula | C23H21N5O3 |
| Molecular Weight | 415.50 Da |
| PubChem Identifier | 52912189 |
Storage & Shipping
| Handling | Toxic, refer to SDS for further information. |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at -20°C. |
For research use only. Not for clinical use.
