PF 670462, casein kinase 1epsilon (CK1epsilon) and CK1delta inhibitor (RMML-00120804)
Cat. No.: RMML-00120804
Category: Inhibitors & Activators
INQUIRY
50 mg
10 mg
Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 99% |
| Key Features | Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor; CAS Number: 950912-80-8; Purity: > 99%; Soluble in water to 100 mM and in DMSO to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | CK1epsilon, CK1delta |
|---|---|
| Biological Description | Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM for CK1ε and CK1δ, respectively). Shows >300-fold selectivity over CK2 and selectivity over more than 40 other kinases. Alters circadian rhythms in vivo.Also available in simple stock solutions (ab146728) - add 1 mL of water to get an exact, ready-to-use concentration. |
| CAS Number | 950912-80-8 |
| Chemical Name | 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride |
| SMILES | Cl.Cl.Nc1nccc(n1)c3c(ncn3C2CCCCC2)c4ccc(F)cc4 |
| Molecular Formula | C19H20FN5.2HCl |
| Molecular Weight | 410.32 Da |
| PubChem Identifier | 51049607 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
|---|---|
| Solubility | Soluble in water to 100 mM and in DMSO to 100 mM |
| Storage & Shipping | Store at room temperature. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
