Recombinant Human GDF 5 Protein (Active) (RMPP-00230894)
Cat. No.: RMPP-00230894
Category: Recombinant Protein
Research Area: Signal Transduction
INQUIRY
100 μg
1 mg
Product Features
| Source | Baculovirus infected Sf9 cells |
|---|---|
| Nature | Recombinant |
| Animal Free | No |
| Tags | GST tag N-Terminus |
| Form | Liquid |
| Applications | SDS-PAGE; WB |
| Key Features | Expression system: Baculovirus infected Sf9 cells; Purity: = 95% Densitometry; Tags: GST tag N-Terminus; Suitable for: SDS-PAGE, WB |
Protein Information
| UniProt ID | P35221 |
|---|---|
| Molecular Weight | 123 kDa including tags |
| Sequence Similarities | Belongs to the vinculin/alpha-catenin family. |
| Protein Length | Full length protein |
| Cellular Localization | Cell membrane and Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell membrane. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries. |
| Tissue Specificity | Expressed ubiquitously in normal tissues. |
| Function | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. |
| Post-translational Modifications | Sumoylated. |
Storage & Shipping
| Shipping and Storage | Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. pH: 7.50Constituents: 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride |
|---|
For research use only. Not for clinical use.
