Recombinant Human IL-11 (RMPP-00231284)
Cat. No.: RMPP-00231284
Category: Growth Factors & Cytokines
INQUIRY
2 μg
10 μg
IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury. Recombinant Human IL-11 is a 19.3 kDa protein consisting of 179 amino acid residues.
Product Features
| Source | E.coli |
|---|---|
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Nature | Recombinant |
| Endotoxin Level | < 1 Eu/μg |
| Cross Reactivity | Human, Monkey, Mouse |
Protein Information
| UniProt ID | P20809 |
|---|---|
| Molecular Weight | 19.3 kDa |
| Molecular Weight Information | Predicted MW is 19201.44 Da. (+/- 10 Da by ESI-TOF). Observed MW is 19202.46 Da. Additional masses 19048.37 are due to residual O-glycans. |
| Sequence Similarities | Belongs to the IL-6 superfamily. |
| Protein Length | Full length protein |
| Cellular Localization | Secreted. |
| Function | Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. |
Storage & Shipping
| Shipping and Storage | Shipped on Dry Ice. |
|---|
For research use only. Not for clinical use.
