Recombinant Human p75 NGF Receptor Protein (Fc Chimera) (Active)

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Recombinant Human p75 NGF Receptor Protein (Fc Chimera) (Active) (RMPP-00230050)

Cat. No.: RMPP-00230050

Category: Growth Factors & Cytokines

Research Area: Immunology

INQUIRY 100 μg 50 μg

Product Features

Source	HEK 293 cells
Purity	> 90% SDS-PAGE.
Nature	Recombinant
Endotoxin Level	< 0.100 Eu/µg
Animal Free	No
Form	Lyophilized
Applications	ELISA; Functional Studies; SDS-PAGE
Key Features	Expression system: HEK 293 cells; Purity: > 90% SDS-PAGE; Endotoxin level: < 0.100 Eu/µg; Active: Yes; Suitable for: ELISA, Functional Studies, SDS-PAGE

Protein Information

UniProt ID	P05112
Molecular Weight	15 kDa
Sequence	HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAAT VLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCP VKEANQSTLENFLERLKTIMREKYSKCSS
Sequence Similarities	Belongs to the IL-4/IL-13 family.
Protein Length	Full length protein
Cellular Localization	Secreted.
Function	Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
Involvement in Disease	Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

Storage & Shipping

Shipping and Storage	Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. pH: 7.4Constituents: 0.39% MES, 5% Trehalose, 1.17% Sodium chloride, PBSLyophilized from 0.22 µm filtered solution. 5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5% This product is an active protein and may elicit a biological response in vivo, handle with caution.

Shipping and Storage

Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.4Constituents: 0.39% MES, 5% Trehalose, 1.17% Sodium chloride, PBSLyophilized from 0.22 µm filtered solution.
5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5%
This product is an active protein and may elicit a biological response in vivo, handle with caution.

For research use only. Not for clinical use.