Recombinant Human PEG10/EDR Protein (RMPP-00230548)
Cat. No.: RMPP-00230548
Category: Growth Factors & Cytokines
Research Area: Signal Transduction
INQUIRY
10 μg
Customer Size
Product Features
| Source | HEK 293 cells |
|---|---|
| Purity | ≥ 95% SDS-PAGE. =95% by HPLC |
| Nature | Recombinant |
| Endotoxin Level | ≤ 0.005 Eu/µg |
| Carrier Free | Yes |
| Animal Free | Yes |
| Form | Lyophilized |
| Applications | MS; SDS-PAGE; HPLC; Functional Studies; Cell Culture |
| Key Features | Expression system: HEK 293 cells; Purity: ≥ 95% SDS-PAGE; Endotoxin level: ≤ 0.005 Eu/µg; Active: Yes; Suitable for: MS, SDS-PAGE, HPLC, Functional Studies, Cell Culture |
Protein Information
| UniProt ID | P61812 |
|---|---|
| Molecular Weight | 46 kDa |
| Molecular Weight Information | Predicted mass is 45592.13 Da (+/- 1-Da by ESI TOF). Multiple peaks are due to proteolytic cleavage during expression. Peak1 (12720 Da, aa303-414); Peak 2 (32170 DA,aa 21-297; Peak 3 (45592 Da, aa 21-414). |
| Sequence | LSTCSTLDMD QFMRKRIEAI RGQILSKLKL TSPPEDYPEP EEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA KEVYKIDMPP FFPSENAIPP TFYRPYFRIV RFDVSAMEKN ASNLVKAEFR VFRLQNPKAR VPEQRIELYQ ILKSKDLTSP TQRYIDSKVV KTRAEGEWLS FDVTDAVHEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP NKSEELEARF AGIDGTSTYT SGDQKTIKST RKKNSGKTPH LLLMLLPSYR LESQQTNRRK KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC PYLWSSDTQH SRVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGKTPKI EQLSNMIVKS CKCS |
| Sequence Similarities | Belongs to the TGF-beta family. |
| Protein Length | Full length protein |
| Cellular Localization | Secreted. |
| Function | TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. |
| Involvement in Disease | A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.Loeys-Dietz syndrome 4Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features. |
| Post-translational Modifications | The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. |
Storage & Shipping
| Shipping and Storage | Shipped at Room Temperature. Store at Room Temperature. Constituents: 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Monobasic dihydrogen potassium phosphate, 10.26% Trehalose This product is an active protein and may elicit a biological response in vivo, handle with caution. |
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For research use only. Not for clinical use.
