Recombinant Human SMAD9 Protein (RMPP-00230727)
Cat. No.: RMPP-00230727
Category: Recombinant Protein
Research Area: Cell Biology
INQUIRY
20 μg
50 μg
Product Features
| Source | E.coli |
|---|---|
| Purity | > 90% SDS-PAGE. |
| Nature | Recombinant |
| Endotoxin Level | ≤ 1.000 Eu/µg |
| Animal Free | No |
| Tags | His tag N-Terminus |
| Form | Lyophilized |
| Applications | SDS-PAGE; Functional Studies |
| Key Features | Expression system: E.coli; Purity: > 90% SDS-PAGE; Endotoxin level: ≤ 1.000 Eu/µg; Active: Yes; Tags: His tag N-Terminus; Suitable for: SDS-PAGE, Functional Studies |
Protein Information
| UniProt ID | Q9Y275 |
|---|---|
| Molecular Weight | 19 kDa including tags |
| Sequence | MHHHHHHLVPRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSF KRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGD ELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISL DGDVTFFGALKLL |
| Sequence Similarities | Belongs to the tumor necrosis factor family. |
| Protein Length | Protein fragment |
| Cellular Localization | Secreted and Cell membrane. |
| Tissue Specificity | Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. |
| Post-translational Modifications | The soluble form derives from the membrane form by proteolytic processing.N-glycosylated. |
Storage & Shipping
| Shipping and Storage | Shipped at room temperature. Store at -20°C. Constituent: 0.16% Sodium phosphate0.2 micron filtered. This product is an active protein and may elicit a biological response in vivo, handle with caution. |
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For research use only. Not for clinical use.
