SAG

SAG SMO is a component of the Hedgehog signaling pathway, which is translocated to the primary cilium after stimulation of the Patched receptor by Hedgehog family ligands, leading to pathway activation. SAG activates SMO via direct binding to the heptahelical bundle. SAG abrogates cyclopamine inhibition of SMO, indicating that it acts downstream of cyclopamine. Improves neuronal differentiation of human induced pluripotent stem cells. Induces proliferation and survival of neuronal and glial precursors in vitro and in vivo. Prevents glucocorticoid neurotoxicity in Math1-Cre, SmoM2 transgenic mice. Rescues cerebellar size and behavioral phenotypes in the Ts65Dn mouse model of Down Syndrome.