ZM 449829, JAK3 inhibitor (RMML-00120830)
Cat. No.: RMML-00120830
Category: Inhibitors & Activators
INQUIRY
50 mg
10 mg
Potent, selective, ATP-competitive JAK3 inhibitor. Potent transglutaminase inhibitor.
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | Potent, selective, ATP-competitive JAK3 inhibitor. Potent transglutaminase inhibitor.; CAS Number: 4452-06-6; Purity: > 98%; Soluble in DMSO and in ethanol; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | JAK3 |
|---|---|
| Biological Description | Potent, selective, ATP-competitive JAK3 inhibitor (pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively). Potent transglutaminase inhibitor (IC50 = 10 nM). Inhibits STAT5 phosphorylation and T cell proliferation. |
| CAS Number | 4452-06-6 |
| Chemical Name | 1-(2-Naphthalenyl)-2-propen-1-one |
| SMILES | C=CC(=O)C1=CC2=CC=CC=C2C=C1 |
| Molecular Formula | C13H10O |
| Molecular Weight | 182.22 Da |
| PubChem Identifier | 3799 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
|---|---|
| Solubility | Soluble in DMSO and ethanol |
| Storage & Shipping | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
