LY2874455, FGF/FGFR inhibitor (RMML-00120755)
Cat. No.: RMML-00120755
Category: Inhibitors & Activators
INQUIRY
25 mg
5 mg
Potent FGF/FGFR inhibitor
Product Features
| Purity | > 98% |
|---|---|
| Key Features | Potent FGF/FGFR inhibitor; CAS Number: 1254473-64-7; Purity: > 98%; DMSO (>4 mg/mL); Form / State: Solid |
Compound Information
| Target Pathways | FGF/FGFR |
|---|---|
| Biological Description | Potent FGF/FGFR inhibitor. Inhibits in vitro autophosphorylation of FGFR-1, FGFR-2, FGFR-3, and FGFR-4 with similar inhibition potency for all four FGFRs (IC50 < 6.4 nM). Exhibits a 6- to 9-fold in vitro and in vivo selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice. |
| Alternative Names | LY-2874455 |
| CAS Number | 1254473-64-7 |
| Chemical Name | (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol |
| SMILES | Clc1cncc(Cl)c1[C@@H](C)Oc3cc4c(/C=C/c2cn(CCO)nc2)nnc4cc3 |
| Molecular Formula | C21H19Cl2N5O2 |
| Molecular Weight | 444.31 Da |
| PubChem Identifier | 46944259 |
Storage & Shipping
| Handling | Refer to SDS for further information. |
|---|---|
| Solubility | DMSO (>4 mg/mL) |
| Storage & Shipping | Shipped at 4°C. Store at -20°C. Store in the dark. Store under desiccating conditions. |
For research use only. Not for clinical use.
