TWS119 (RMML-00121072)
Cat. No.: RMML-00121072
Category: Inhibitors & Activators
INQUIRY
1 mg
5 mg
TWS119 is a potent disubstituted pyrrolopyrimidine inhibitor of glycogen synthase kinase 3 beta. GSK3 is a serine/threonine kinase that is a key inhibitor of the WNT pathway; therefore TWS119 functions as a WNT pathway activator. Maintains the bi-potent, quiescent state in hepatic stellate cells of Wistar rats. Induces differentiation of mouse embryonal carcinoma and embryonic stem cells to neurons. Induces production of T memory stem cell-like. Inhibits cell proliferation and induces apoptosis in human alveolar rhabdomyosarcoma cells.
Product Features
| Purity | ≥ 90% |
|---|---|
| Applications | Differentiation, Maintenance |
| Cross Reactivity | Human, Mouse, Non-Human Primate, Other, Rat |
Compound Information
| Target Pathways | WNT |
|---|---|
| CAS Number | 601514-19-6 |
| Molecular Formula | C₁₈H₁₄N₄O₂ |
Storage & Shipping
| Handling | Refer to SDS for further information. |
|---|
For research use only. Not for clinical use.
