Anti-FGF2 Antibody (RMAB-0250575)
Cat. No.: RMAB-0250575
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to FGF2
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR20145-219 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse |
| Immunogen | Recombinant fragment. |
| Applications | WB, IP, ICC/IF, Indirect ELISA, Flow Cyt (Intra) |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to FGF2; Suitable for: WB, IP, ICC/IF, Indirect ELISA, Flow Cyt (Intra); Reacts with: Mouse, Human |
Target Information
| Target Symbol | FGF2 |
|---|---|
| Target Name | Fibroblast growth factor 2 |
| UniProt ID | P09038 |
| Cellular Localization | Secreted. Nucleus. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57. |
| Function | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:2346917). |
| Post-translational Modifications | Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion. Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing. |
| Sequence Similarities | Belongs to the heparin-binding growth factors family. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
