JK 184, Hedgehog signaling inhibitor (RMML-00120761)
Cat. No.: RMML-00120761
Category: Inhibitors & Activators
INQUIRY
50 mg
10 mg
Potent Hedgehog signaling inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 99% |
| Key Features | Potent Hedgehog signaling inhibitor; CAS Number: 315703-52-7; Purity: > 99%; Soluble in DMSO to 100 mM and in ethanol to 25 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | Hh |
|---|---|
| Biological Description | Potent Hedgehog (Hh) signaling inhibitor. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Potently inhibits microtubule assembly. Additionally displays antitumor activity. |
| CAS Number | 315703-52-7 |
| Chemical Name | N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl-2-thiazolamine |
| Molecular Formula | C19H18N4OS |
| Molecular Weight | 350.44 Da |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM and in ethanol to 25 mM |
| Storage & Shipping | Store at 4°C. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
