Metformin

Metformin is an activator of the AMP-activated protein kinase. It acts as an antihyperglycemic agent to lower plasma glucose levels and improve insulin sensitivity. This product is provided as a hydrochloride salt of the molecule.   Promotes neurogenesis in mouse cortical precursors and human forebrain neural precursors in vitro, and in adult mouse central nervous system in vivo, via activation of the aPKC-CBP pathway. Stimulates glucose uptake in skeletal muscle and suppresses gluconeogenesis in the liver. Reduces fatty liver disease in obese. Inhibits secretion of the adipocyte hormone leptin in mouse brown adipocytes. Inhibits tumor cell growth in various cancer cell lines and in mouse xenograft models. Inhibits the inflammatory response associated with cancer stem cell growth.