Recombinant Human PDGF AB Protein (Animal Free) (RMPP-00230553)
Cat. No.: RMPP-00230553
Category: Recombinant Protein
Research Area: Signal Transduction
INQUIRY
10 μg
1 mg
Product Features
| Source | HEK 293 cells |
|---|---|
| Purity | > 95% SDS-PAGE. |
| Nature | Recombinant |
| Endotoxin Level | < 1.000 Eu/µg |
| Animal Free | No |
| Tags | His tag C-Terminus |
| Form | Lyophilized |
| Applications | SDS-PAGE |
| Key Features | Expression system: HEK 293 cells; Purity: > 95% SDS-PAGE; Endotoxin level: < 1.000 Eu/µg; Active: Yes; Tags: His tag C-Terminus; Suitable for: SDS-PAGE |
Protein Information
| UniProt ID | Q8NBP7 |
|---|---|
| Molecular Weight | 73 kDa including tags |
| Sequence | QDEDGDYEELMLALPSQEDSLVDEASHVATATFRRCSKEAWRLPGTYVVV LMEETQRLQV EQTAHRLQTWAARRGYVIKVLHVFYDLFPGFLVKMSSD LLGLALKLPHVEYIEEDSLVFAQSIPWNLERIIPAWQQTEEDSSPDGSSQ VEVYLLDTSIQSGHREIEGRVTITDFNSVPEED GTRFHRQASKCDSHG THLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIR KSQ LIQPSGPLVVLLPLAGGYSRILNTACQRLARTGVVLVAAAGNFRDDACLY SPASAPE VITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASS DCSTCYMSQSGTSQAAAHV AGIVAMMLNRDPALTLAELRQRLILFSTK DVINMAWFPEDQRVLTPNRVATLPPSTQETG GQLLCRTVWSAHSGPTR TATATARCAPEEELLSCSSFSRSGRRRGDRIEAIGGQQVCKAL NAFGG EGVYAVARCCLLPRVNCSIHNTPAARAGPQTPVHCHQKDHVLTGCSFHWE VENLR AQQQPLLRSRHQPGQCVGHQEASVHASCCHAPGLECKIKEHGI AGPAEQVTVACEAGWTL TGCNVLPGASLPLGAYSVDNVCVARIRDAGR ADRTSEEATVAAAICCRSRPSAKASWVHQ |
| Sequence Similarities | Belongs to the peptidase S8 family. Contains 1 peptidase S8 domain. |
| Protein Length | Full length protein |
| Cellular Localization | Secreted. |
| Tissue Specificity | Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. |
| Function | May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis. |
| Involvement in Disease | Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3). FH3 inheritance is autosomal dominant. |
| Post-translational Modifications | The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Store at 4°C prior to reconstitution. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA). pH: 7.40Constituents: 95% PBS, 5% TrehaloseLyophilized from 0.22 µm filtered solution This product is an active protein and may elicit a biological response in vivo, handle with caution. |
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For research use only. Not for clinical use.
