SMI-4a, ATP-competitive Pim kinase inhibitor (RMML-00120832)
Cat. No.: RMML-00120832
Category: Inhibitors & Activators
INQUIRY
5 mg
25 mg
Potent, selective, cell-permeable, ATP-competitive Pim kinase inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | ≥ 98% |
| Key Features | Potent, selective, cell-permeable, ATP-competitive Pim kinase inhibitor; CAS Number: 438190-29-5; Soluble in DMSO to 100 mM and in ethanol to 100 mM with warming; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | Pim kinase |
|---|---|
| Biological Description | Potent, selective, cell-permeable, ATP-competitive Pim-1 kinase inhibitor (IC50 = 17 nM). Moderately potent against Pim-2 kinase. Selective versus a panel of other serine/threonine and tyrosine kinases. Inhibits the growth of myeloid and lymphoid cell lines. Induces cell cycle arrest in leukemia and prostate cancer cells. |
| Alternative Names | TCS PIM-1 4a |
| CAS Number | 438190-29-5 |
| Chemical Name | 5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione |
| SMILES | C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2 |
| Molecular Formula | C11H6F3NO2S |
| Molecular Weight | 273.23 Da |
| PubChem Identifier | 1361334 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM and in ethanol to 100 mM with warming |
| Storage & Shipping | Shipped at room temperature. Store at -20°C. |
For research use only. Not for clinical use.
