PF-04449913 (Glasdegib) (RMML-00120774)
Cat. No.: RMML-00120774
Category: Inhibitors & Activators
INQUIRY
1 mg
potent smoothened (SMO) inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | ≥ 98% |
| Key Features | Potent smoothened (SMO) inhibitor; CAS Number: 1095173-27-5; Purity: ≥ 98%; ~20 mg/mL DMSO; Form / State: Solid; Source: Synthetic |
Compound Information
| Biological Description | Potent and orally bioavailable smoothened (SMO) inhibitor. PF-04449913 binds to human SMO with an IC50 of 4 nM. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model. |
|---|---|
| Alternative Names | Glasdegib |
| CAS Number | 1095173-27-5 |
| Chemical Name | 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea |
| SMILES | CN1CCC(CC1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N |
| Molecular Formula | C21H22N6O |
| Molecular Weight | 374.40 Da |
| PubChem Identifier | 25166913 |
Storage & Shipping
| Handling | Toxic, refer to SDS for further information. |
|---|---|
| Solubility | ~20 mg/mL DMSO |
| Storage & Shipping | Shipped at 4°C. Store at -20°C. |
For research use only. Not for clinical use.
